Hpv Vaccine, The Cochrane Library, And Google Scholar

The literature search for this review was conducted using several databases including CINAHL, PubMed, the Cochrane Library, and Google Scholar. Search terms included â€Å" human papillomavirus vaccine†, â€Å" human papillomavirus†, â€Å"HPV†, â€Å" human papillomavirus safety and effectiveness†, â€Å"human papillomarvirus vaccination rates†, â€Å"HPV randomized controlled trials and systematic reviews†. Since licensure of the HPV vaccine in 2006, HPV vaccine coverage among US adolescents has increased but remains low compared with other recommended vaccines. Studies show that the influence of accurate information about vaccines is maximized when conveyed from provider to parent or patient and for parents, healthcare providers such as physicians or†¦show more content†¦In response to this serious health issue, more than 20 years of incremental research culminated in the development of HPV vaccines that elicit strong immunoge nic reactions without the risk of causing infection. A review of the literature has revealed that persistent infection with an oncogenic strain of HPV is the known cause of cervical cancer and of the 40 HPV types that affect the genital area, at least 15 types are known to be oncogenic or cancer causative (Armstrong, 2010). Based on clinical trials, HPV vaccination is effective against the occurrence of precancerous lesions and according to Armstrong (2010), studies of the quadrivalent HPV vaccine revealed a 98% protection against high-grade precancerous lesions, whereas for bivalent HPV vaccine 93% efficacy has been demonstrated in females to HPV 16 and 18 who completed the 3-dose vaccine series prior to engaging in any type of sexual actitivities. Cook et al (2010), acknowledges that there is no research available on long term efficiency of vaccines and also not everyone who initiates the vaccine series completes all 3 doses or completes all doses in the recommended 6-month ti me frame; this noncompliance and